Table 6.
Significant pathways at the nominal 0.005 level of the Hotelling T-square test *
| Related Function | Kegg Pathway | Pathway description | Number of genes | p-value |
| Cell Growth & Death | hsa04210 | Apoptosis | 9 | 1.20E-06 |
| hsa04110 | Cell cycle | 10 | 2.10E-06 | |
| Signal Transduction | hsa04020 | Calcium signaling pathway | 13 | 1.80E-06 |
| hsa04010 | MAPK signaling pathway | 19 | 1.11E-05 | |
| hsa04310 | Wnt signaling pathway | 10 | 1.24E-05 | |
| hsa04630 | Jak-STAT signaling pathway | 7 | 3.64E-05 | |
| hsa04070 | Phosphatidylinositol signaling system | 7 | 8.03E-05 | |
| hsa04370 | VEGF signaling pathway | 5 | 0.000333 | |
| Immune System | hsa04650 | Natural killer cell mediated cytotoxicity | 7 | 1.67E-05 |
| hsa04640 | Hematopoietic cell lineage | 6 | 2.63E-05 | |
| hsa04662 | B cell receptor signaling pathway | 9 | 5.01E-05 | |
| hsa04660 | T cell receptor signaling pathway | 6 | 5.06E-05 | |
| hsa04664 | Fc epsilon RI signaling pathway | 7 | 9.76E-05 | |
| hsa04610 | Complement and coagulation cascades | 5 | 0.0001297 | |
| hsa04620 | Toll-like receptor signaling pathway | 5 | 0.003536 | |
| Signaling Molecules and Interaction | hsa04080 | Neuroactive ligand-receptor interaction | 12 | 1.00E-07 |
| hsa04060 | Cytokine-cytokine receptor interaction | 15 | 3.00E-07 | |
| hsa04514 | Cell adhesion molecules (CAMs) | 9 | 1.50E-05 | |
| hsa04512 | ECM-receptor interaction | 8 | 0.0004294 | |
| Endocrine System | hsa04910 | Insulin signaling pathway | 8 | 6.00E-06 |
| hsa04920 | Adipocytokine signaling pathway | 5 | 6.90E-06 | |
| hsa03320 | PPAR signaling pathway | 6 | 3.42E-05 | |
| hsa04912 | GnRH signaling pathway | 8 | 3.66E-05 | |
| Cell Communication | hsa04510 | Focal adhesion | 17 | 9.20E-06 |
| hsa04520 | Adherens junction | 5 | 2.95E-05 | |
| hsa04540 | Gap junction | 10 | 3.89E-05 | |
| hsa04530 | Tight junction | 10 | 4.48E-05 | |
| Others | hsa04810 | Regulation of actin cytoskeleton | 11 | 3.90E-06 |
| hsa00260 | Glycine, serine and threonine metabolism | 6 | 1.54E-05 | |
| hsa00190 | Oxidative phosphorylation | 17 | 3.14E-05 | |
| hsa00230 | Purine metabolism | 18 | 3.22E-05 | |
| hsa00500 | Starch and sucrose metabolism | 9 | 7.68E-05 | |
| hsa00980 | Metabolism of xenobiotics by cytochrome P450 | 7 | 8.06E-05 | |
| hsa00240 | Pyrimidine metabolism | 12 | 0.0001352 | |
| hsa04730 | Long-term depression | 6 | 0.0002265 | |
| hsa04720 | Long-term potentiation | 7 | 0.0003216 | |
| hsa04360 | Axon guidance | 11 | 0.0007991 |
* Significance threshold of permutation tests: 0.005
Significance threshold of Hotelling's T-square tests: 0.005
Number of principal components for Hotelling's T-square tests: 3
Square tests: 3