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. 2008 Jun 5;5:44. doi: 10.1186/1742-4690-5-44

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Copyright © 2008 Das et al; licensee BioMed Central Ltd.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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U3 and TAR mutations improve SIV-rtTA replication. (A) PM1 T-cells were transfected with 5 μg of the original (grey symbols) or LTR-mutated SIV-rtTA proviral plasmid (black symbols) and cultured with or without dox (closed and open symbols, respectively). Virus replication was monitored by measuring the reverse transcriptase level in the culture supernatant. (B) Cells were transfected with 1 μg SIV-rtTA or SIVmac239 proviral plasmid and cultured with dox (SIV-rtTA variants) or without dox (SIVmac239).