Table 3.
Association of FGFR3 expression levels and presence of mutation
| GRADE/STAGE1 | Low FGFR3 expression | High FGFR3 expression | Total | P value (Fisher’s exact test) | ||
|---|---|---|---|---|---|---|
| wildtype | mutant | wildtype | mutant | |||
| 1 | 2 (17%) | 1 (8.3%) | 2 (16.7%) | 7 (58.3%) | 12 | 0.2364 |
| 2 | 9 (16%) | 5 (9.0%) | 9 (29.3%) | 32 (58.2%) | 55 | 0.007 |
| 3 | 34 (47.4%) | 3 (4.2%) | 21 (29.2%) | 14 (19.4%) | 72 | 0.0019 |
| Ta | 13 (19.4%) | 7 (10.5%) | 9 (13.4%) | 38 (56.7%) | 67 | <0.0001 |
| T1 | 11 (42.3%) | 0 | 4 (15.4%) | 11 (42.3%) | 26 | <0.0001 |
| T2 | 19(48.7%) | 2 (5.1%) | 15 (38.5%) | 3 (7.7%) | 39 | 0.0012 |
1
Tumours in which staining was scored differently in different regions of the section (n=10 including one pTx sample) are not included