Table 1.
Population characteristics (±SD) according to quintiles of logVPT. χ2 test was used to identify gender differences and Kruskal-Wallis test was used for fasting glucose, Glucose120, sIL-6, TNF-αR1, TNF-αR2, SuralAmp and PeronealAmp due to their skewed distribution. Abbreviations are explained in the footnote.
| Variable | Overall | 1st | 2nd | 3rd | 4th | 5th | p |
|---|---|---|---|---|---|---|---|
| Age (yrs) | 67.6 ± 14.5 | 56.6 ± 15.5 | 61.9 ± 13.0 | 67.2 ± 10.5 | 74.2 ± 10.2 | 78.5 ± 10.7 | < 0.001 |
| Gender (f/m) | 263/260 | 73/34 | 55/48 | 56/48 | 47/58 | 32/72 | < 0.001 |
| Height (cm) | 168.88 ± 9.46 | 166.96 ± 8.06 | 169.22 ± 9.94 | 168.06 ± 8.77 | 168.93 ± 9.99 | 171.29 ± 10.07 | 0.018 |
| BMI (kg/m2) | 26.11 ± 4.43 | 26.75 ± 6.11 | 27.25 ± 4.72 | 26.97 ± 4.61 | 26.60 ± 4.05 | 26.60 ± 4.05 | 0.522 |
| Fasting Glucose (mg/dl) | 94.69 ± 15.24 | 93.78 ± 18.52 | 92.73 ± 10.41 | 96.90 ± 13.65 | 95.48 ± 17.63 | 94.54 ± 14.46 | 0.061 |
| Glucose120 (mg/dl) | 125.97 ± 52.36 | 122.67 ± 54.64 | 110.18 ± 36.25 | 131.69 ± 59.05 | 130.26 ± 53.46 | 136.51 ± 52.38 | 0.003 |
| sIL-6 (pg/ml) | 2.32 ± 1.55 | 1.65 ± 1.00 | 2.04 ± 1.25 | 2.39 ± 1.47 | 2.41 ± 1.69 | 3.07 ± 1.87 | < 0.001 |
| sIL-6R (pg/ml) | 35259.9 ± 9337.3 | 34147.6 ± 8034.6 | 34429.4 ± 9019.0 | 36451.8 ± 10795.4 | 33353.6 ± 7309.6 | 372888.6 ± 103888.1 | 0.326 |
| TNF-αR1 (pg/ml) | 1548.64 ± 554.31 | 1309.17 ± 235.81 | 1373.07 ± 281.38 | 1467.57 ± 486.88 | 1536.79 ± 286.46 | 2012.53 ± 829.86 | < 0.001 |
| TNF-αR2 (pg/ml) | 2610.54 ± 1016.77 | 2171.23 ± 410.00 | 2266.62 ± 466.99 | 2510.67 ± 1056.88 | 2499.44 ± 512.16 | 3500.35 ± 1421.63 | < 0.001 |
| SuralNCV (m/s) | 46.4 ± 7.6 | 47.4 ± 7.1 | 46.8 ± 6.4 | 46.1 ± 7.7 | 45.9 ± 8.0 | 45.8 ± 9.1 | 0.600 |
| SuralAmp (mV) | 8.44 ± 7.64 | 10.66 ± 9.46 | 9.36 ± 8.57 | 9.08 ± 7.68 | 7.03 ± 5.39 | 5.09 ± 3.63 | < 0.001 |
| PeronealNCV (m/s) | 47.4 ± 7.4 | 50.0 ± 5.7 | 49.2 ± 7.3 | 48.2 ± 5.4 | 45.7 ± 5.8 | 43.2 ± 9.9 | < 0.001 |
| PeronealAmp (mV) | 3.8 ± 2.4 | 4.85 ± 2.38 | 4.33 ± 2.64 | 4.13 ± 2.12 | 3.3 ± 1.7 | 2.3 ± 1.9 | < 0.001 |
| TFT | 23.6 ± 3.9 | 24.3 ± 3.9 | 24.4 ± 4.1 | 23.7 ± 3.7 | 22.6 ± 3.6 | 23.1 ± 3.6 | 0.037 |
| SBT | 1.4 ± 1.8 | 1.0 ± 1.1 | 1.3 ± 2.1 | 1.5 ± 1.8 | 1.5 ± 1.9 | 1.6 ± 1.9 | 0.432 |
Abbreviations: Glucose120: serum glucose at 120 minutes of the oral glucose tolerance test
sIL-6: Serum Interleukin-6
sIL-6R: Serum Interleukin-6 Receptor
TNF-αR1: Tumor necrosis factor- α receptor 1
TNF-αR2: Tumor necrosis factor- α receptor 2
SuralNCV: Sural nerve conduction velocity
SuralAmp: Sural nerve amplitude
peronealNCV: Peroneal nerve conduction velocity
PeronealAmp: Peroneal nerve amplitude
TFT: Total finger taps
SBT: Short Blessed test