Table 1.
Summary of effects of NO modulation on acute cardiac allograft survival and rejection
| Source | Agent | Graft Survival | Histological Rejection |
|---|---|---|---|
| Non-selective NOS inhibitors | |||
| Winlaw (1995) | L-NMMA | ⬆ | ➡ |
| Menon (1998) | L-NMMA | ⬆ | ➡ |
| Bastian (1994) | L-NMMA | ➡ | n.d. |
| Paul (1996) | L-NAME | ⬇ | |
| Yamamoto (2007) | L-NMMA | ➡ | n.d. |
| NO neutralizers | |||
| Cooper (1998) | PDTC | ⬆ | ➡ |
| Pieper (2002) | DETC-Fe | ⬆ | ⬇ |
| Roza (2000) | NOX-100 | ⬆ | ➡ |
| Pieper (2001) | ⬆ | ||
| Pieper (2004) | NOX-700 | ⬆ | ⬇ |
| Pieper (2002) | AMD6221 | ⬆ | ⬇ |
| iNOS inhibitors | |||
| Worrall (1995) | Aminoguanidine | ⬆ | ⬇ |
| Takahashi (2000) | Aminoguanidine | ⬆ | ⬇ |
| Szabolcs (2002) | BBS-1 | ⬆ | ⬇ |
| BBS-2 | ⬆ | ➡ | |
| Pieper (2004) | L-NIL | ⬆ ➡ | ⬇ |
| Pterin-based NOS inhibitor | |||
| Brandacher (2001) | 4-aminobiopterin | ⬆ | ⬇ |
| Brandacher (2006) | 4-aminobiopterin | ⬆ | ⬇ |
| iNOS knockout | |||
| Koglin (1999) | INOS−/− recipients | n.d. | ⬇ |
| Mannon (1999) | iNOS−/− recipients | ➡ | ➡ |
| iNOS−/− donors | ➡ | ➡ | |
| Lee (2000) | iNOS−/− donors | ⬇ | n.d. |
| Szabolcs (2001) | iNOS−/− recipients | ➡ | ➡ |
| iNOS−/− recipients | ➡ | ➡ | |
| iNOS−/− donors and recipients | ⬆ | ⬇ | |
DETC-Fe, diethyldithiocarbamate-iron complex; L-NAME, L-nitroarginine methyl ester; L-NIL, N6-(1-iminoethyl)-L-lysine; L-NMMA; L-NG-monomethylarginine; PDTC, pyrrolidine dithiocarbamate; ⬆ increased; ⬇ decreased; ➡ unchanged; n.d., not determined
n.d. (not determined)