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. 2008 Jul 11;283(28):19730–19738. doi: 10.1074/jbc.M801288200

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Copyright © 2008, The American Society for Biochemistry and Molecular Biology, Inc.

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FIGURE 5. — Specific activities of retinoid-processing enzymes in RPE homogenates from dark- and light-adapted mice. A, LRAT activities in wild-type and rgr^-^/^- RPE homogenates using all-trans-ROL as substrate. Expressed as picomoles of all-trans-RE synthesized per mg of protein per min. Asterisks denote significant differences between LRAT activities in the dark and light (p = 0.008 for wild-type and 0.022 for rgr^-^/^- mice). B, all-trans-REH activities in RPE homogenates from wild-type, rgr^-^/^-, rpe65^-^/^-, and rgr^-^/^-, rpe65^-^/^- double knock-out mice. The substrate was all-trans-retinyl acetate, and activities are expressed as all-trans-ROL synthesized per mg of protein per min. Asterisks denote significant differences between all-trans-REH activities in the dark and light (p = 0.0009 for wild-type and p = 0.0001 for rpe65^-^/^- mice). C, isomerase activities in wild-type and rgr^-^/^- RPE-homogenates using all-trans-retinyl palmitate as substrate. Expressed as picomoles of 11-cis-ROL synthesized per mg of protein per min. Asterisks denote significant differences between isomerase activities in the dark and light (p = 0.024 for wild-type and p = 0.003 for rgr^-^/^- mice). D, 11-cis-RDH activities in wild-type and rgr^-^/^- RPE homogenates using 11-cis-RAL and NADH as substrates. Expressed as picomoles of 11-cis-ROL per mg of protein per min. Asterisk denotes a significant difference between 11-cis-RDH activities in the dark and light for rgr^-^/^- mice (p = 0.003).