TABLE 3.

Plasma glucose and hormone responses during day 2 insulin-induced hypoglycemia

Time point (min)	Glucose (mg/dl)	Glucagon (pg/ml)	Epinephrine (pg/ml)	Norepinephrine (pg/ml)	ACTH (pg/ml)	Corticosterone (ng/ml)
Single hypoglycemia (n = 11)
0	104 ± 7	62 ± 13	120 ± 25	363 ± 30	11 ± 3	37 ± 6
60	37 ± 3	494 ± 56	3,811 ± 540	925 ± 91	226 ± 30	223 ± 12
120	25 ± 2	428 ± 40	3,640 ± 525	1,022 ± 85	200 ± 19	250 ± 21
Recurrent hypoglycemia (n = 12)
0	118 ± 3	70 ± 15	130 ± 19	311 ± 40	9 ± 2	26 ± 7
60	38 ± 3	222 ± 43*	1,470 ± 325*	744 ± 75*	181 ± 19	190 ± 20
120	25 ± 1	231 ± 34*	2,500 ± 490	1,322 ± 180	192 ± 20	223 ± 22
Antecedent hindbrain 5TG (n = 11)
0	112 ± 4	69 ± 13	129 ± 30	393 ± 44	13 ± 3	36 ± 5
60	41 ± 3	513 ± 56	3,806 ± 344	1,154 ± 92	243 ± 42	208 ± 9
120	27 ± 2	403 ± 71	4,248 ± 618	1,602 ± 170	165 ± 17	231 ± 10
Antecedent third ventricular 5TG (n = 11)
0	105 ± 7	65 ± 6	142 ± 18	352 ± 41	9 ± 3	28 ± 7
60	37 ± 3	210 ± 21*	1,162 ± 120*	723 ± 70*	220 ± 30	180 ± 17
120	28 ± 2	290 ± 53	3,325 ± 460	1,205 ± 180	211 ± 35	195 ± 19

Data are means ± SE; n, no. of rats.

^*P ≤ 0.05 vs. SH.