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. Author manuscript; available in PMC: 2008 Jul 7.
Published in final edited form as: Free Radic Biol Med. 2006 Jul 21;41(8):1338–1350. doi: 10.1016/j.freeradbiomed.2006.07.015

Figure 4. The steady-state concentration of H2O2 in cells can be a function of the level of MnSOD.

Figure 4

Figure 4

Figure 4

Figure 4

The kinetic model clearly demonstrates that when K < 1 for Rxn 1 the level of SOD will determine the flux of H2O2 as well as its steady-state level. (A) K= 1000; (B) K= 10; (C) K= 0.1; (D) K= 0.001. The different values for the equilibrium constant were achieved by varying the rate constant for the reverse reaction of Rxn 1, keeping the value of the forward rate constant at 8 × 103 M−1 s−1. In the kinetic model, the capacity to remove H2O2 was kept constant.