Down-regulation of 6 IFNα/β-inducible genes in 8 patients correlates with improvement in clinical disease from time point 1 (active) to time point 2 (improving). A, Gene expression studies and analysis of paired blood samples from 2 visits between which clinical improvement occurred, in 8 patients, showed marked down-regulation of multiple IFNα/β-inducible gene transcripts. Six of these genes are shown. B, In patient BGE92, with refractory active DM, expression of most of these 6 genes increased or remained unchanged in serial samples. See Figure 1 for definitions.