Fig. 2.

MeCP2 binds to the promoter region of six target genes. ChIP with anti-MeCP2 antibody shows that MeCP2 binds to the promoter regions of activated targets Sst, Oprk1, Gamt, and Gprin1, and repressed targets Mef2c and A2bp1. The red line indicates the location of the probe and primers (relative to the start site (+1), in bps or in kb, k) and the closest CpG islands in the promoter region are depicted. Quantitative real-time PCR values were normalized to the input and plotted as fold enrichment over Mecp2-null (N ≥ 3, * p≤0.03, t test).