Table 1.

Comparison of Selected Structural Motifs of MoMLV RT and HIV-1 RT

Domain/Subdomain Motife	MoMLV RT residues	HIV-1 RT residuesa
Fingers	41–124; 160–192	1–84; 120–150
Palm	1–40; 125–159; 193–275	85–119; 151–243
Fingers/Palm Thumb	1–275 276–361	1–243 244–322
Connection	362–496	323–437
RNase H	497–671	438–560
Polymerase active site	Asp150, Asp224, Asp225	Asp110, Asp185, Asp186
RNase H active site	Asp524, Glu562, Asp583, Asp653	Asp443, Glu478, Asp498, Asp549
YXDD	Tyr222, Val223, Asp224, Asp225	Tyr183, Met184, Asp185, Asp186
Polymerase Primer Grip	267–274	228–235
MGBT	295–318	255–268
RNase H Primer Grip	Val402b, Gly403b, Trp404b, Ser557, Ala558, Gln559, Arg560, Tyr586, Thr590	p66:Gly359, Ala360, His361, Thr473, Asn474, Gln475, Lys476, Tyr501, Ile505
	N/A c	p51:Lys395, Glu396
RNase H Template Contactsd	Leu529, Ala558, Gln559, Arg585, His638	p66:Arg448, Asn474, Gln475, Gln500, His539
	N/Ac	p51:Lys390
dNTP BP	Asp153, Phe155, Phe156, Gln190, Val223	Asp113, Tyr115, Phe116, Gln151, Met184
NNRTI BP	N/A	100 –110; 180 –190; 220 –240

^aDomain/subdomain divisions taken from (Rodgers et al., 1995)

^bNot previously characterized, since the MoMLV connection subdomain structure was unknown

^cNo p51 analog is known in this context

^dSome residues are in common with those of the primer grip

^eAbbreviations: MGBT = Minor groove Binding Tract;

dNTP BP = dNTP Binding Pocket;

NNRTI BP = NNRTI Binding Pocket;