Table 2.
Domain or Subdomain | MoMLV RT Residues | HIV-1 RT Residuesa | Secondary structure |
---|---|---|---|
Fingers/Palm | 68–84 | 28–43 | α-helix |
194–214 | 155–175 | α-helix | |
217–222 | 178–183 | β-strand | |
225–230 | 186–191 | β-strand | |
233–250 | 195–212 | α-helix | |
264–269 | 225–230 | β-strand | |
271–275 | 232–236 | β-strand | |
Thumb | 295–308 | 255–268 | α-helix |
312–315 | 273–276 | β-strand | |
316–323 | 277–284 | α-helix | |
343–356 | 299–312 | α-helix | |
Connection | 391–401 | 348–358 | β-strand |
411–427 | 366–382 | α-helix | |
439–449 | 395–405 | α-helix | |
452–457 | 408–413 | β-strand | |
RNase H | 519–528 | 438–447 | β-strand |
533–540 | 452–459 | β-strand | |
547–552 | 463–468 | β-strand | |
559–573 | 475–489 | α-helix | |
577–582 | 492–497 | β-strand | |
584–592 | 499–507 | α-helix | |
615–626 | 516–527 | α-helix | |
629–634 | 530–535 | β-strand | |
648–657 | 544–553 | α-helix |
Common regions listed here are from PDB code 1HYS.
Other HIV-1 RT structures might contain more gaps, thus fewer of the representatives listed were used in those comparisons.
The 2HMI structure has its RNase H extended to residue 558.