Table 3.

Linkage Results for the Neuropsychological Measures and the Combined Score

Task	Chr.a	Position (cM)	Locationb	Marker	LOD Score	p Value	Empirical p Valuec
Executive/cognitive tasks
Stop task	12	119.05	12q23.3	rs1862032	2.627	.0003	ns
Shifting attentional set	-	-	-	-	-	-	-
Time test	4	202.6	4q35.2	rs996026	2.111	.0009	ns
Visuo-spatial sequencing	3	44.01	3p24.3	rs680930	2.112	.0009	ns
Digit span	2	14.17	2p25.2	rs1079417	2.022	.0011	ns
	13	0.0004	13q12.11	rs1974047	3.959	.00001	.025
	14	102.71	14q32.13	rs1007813	2.471	.0004	ns
Motor tasks
Pursuit	8	112.26	8q22.3	rs1460239	2.570	.0003	ns
Tracking	-	-	-	-	-	-	-
Tapping	9	51.1	9p21.2	rs9103	2.337	.0005	ns
Baseline speed	-	-	-	-	-	-	-
Motor timing	2	142.45	2q21.1	rs985162	3.944	.00001	.042
	2	27.34	2p25.1	rs1309	2.195	.0007	ns
	17	66.1	17q12	rs1859212	2.338	.0005	ns
Combined score	2	135.13	2q14.3	rs1028184	2.516	.0003	ns
	12	0.86	12p13.33	rs2107614	2.878	.00014	ns

^aChromosome.

^bMost likely cytogenetic location according to draft genome-sequence data.

^cEmpirical p values were derived with the –simulate option featured in the Merlin software by the running of 1000 simulations under the null hypothesis of no linkage, while preserving the original phenotypes, family structures, allele frequencies, linkage disequilibrium (LD) structure, and missing-data pattern.