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. Author manuscript; available in PMC: 2009 Jun 1.
Published in final edited form as: Biochim Biophys Acta. 2008 Feb 20;1783(6):1211–1219. doi: 10.1016/j.bbamcr.2008.01.032

Figure 6.

Figure 6

TGZ suppresses human EP4 promoter activity. Each human EP4 promoter construct (pEP4-1), other deletion constructs (pEP4-2 to 4) or pGL3-basic vector was transfected into T98G cells for 24h. The cells were treated with Control (0.1% Me2SO) or TGZ (20 µM) for 24h (A). The pEP4-3 or pGL3 was transfected into T98G cells for 24h. The transfected cells were treated with 5 PPARγ ligands (20 µM TGZ, 30 µM CGZ, 10 µM RGZ, 10 µM MCC, or 10 µM PGZ) or one PPARα ligand (10 µM Wy14643) for 24h (B). Luciferase activity was measured by a dual luciferase assay system. The bar graphs represent mean ± S.D. of RLU of three experiments. *P<0.01, significant compared with RLU of Control.