TABLE 1.
Comparison of the in vitro antimalarial susceptibilities of P. vivax and P. falciparum isolates from Mae Sod, Thailand
| Therapeutic |
P. vivaxa
|
P. falciparum
|
Pb | ||
|---|---|---|---|---|---|
| No. of isolates | Median IC50 (range) (nM) | No. of isolates | Median IC50 (range) (nM) | ||
| Ritonavir | 14 | 2,233 (732-7,738) | 19 | 9,664 (909-21,103) | <0.001 |
| Saquinavir | 15 | 4,230 (1,326-8,452) | 19 | 8,305 (1,105-26,269) | 0.018 |
| Chloroquine | 14 | 38 (7-1,264) | 18 | 152 (32-380) | <0.001 |
| Artesunate | 15 | 8 (1-23) | 19 | 8 (1-27) | 0.682 |
| Mefloquine | 16 | 69 (30-177) | 17 | 137 (42-341) | 0.028 |
a
Analysis of Plasmodium vivax was restricted to isolates with an RT of >1.
b
Underlined values indicate that the correlation is significant at least at the 0.05 level.