TABLE 4.
Characterization of CBR-2092 single-step mutants derived from a rifampin-sensitive strain
| Mutation identified in rpoB | No. of independent isolations | Broth microdilution MIC (μg/ml)
|
||
|---|---|---|---|---|
| Rifampin | CBR-2092 | Ciprofloxacin | ||
| Wild-type parent | NRa | 0.008 | 0.015 | 0.25 |
| H481Y | 12 | >64 | 0.12 | 0.25 |
| Q468L | 1 | >64 | 0.25 | 0.25 |
| Q468K | 1 | >64 | 0.50 | 0.25 |
| H481D | 1 | >64 | 0.25 | 0.25 |
| H472 (insertion) | 1 | 32 | 0.12 | 0.25 |
| D471Y | 2 | 16 | 0.25 | 0.50 |
| E473 (insertion) | 1 | 8 | 0.25 | 0.25 |
| H481N | 1 | 2 | 0.25 | 0.25 |
| N474K | 2 | 2 | 0.25 | 0.25 |
| A477V | 2 | 1 | 0.12 | 0.25 |
| D471G | 4 | 0.25 | 0.25 | 0.25 |
a
NR, not relevant.