. 2008 Apr 28;52(7):2313–2323. doi: 10.1128/AAC.01649-07

TABLE 5.

Characterization of CBR-2092 single-step mutants derived from rifampin-resistant strains

Strain	Parent strain	Parent strain genotype	Selection concn (μg/ml)	Ending strain genotype	CBR-2092 broth microdilution MIC (μg/ml)
CB1522	CB1244	rpoB^H481Y	NA^a	NA	0.25
CB1523	CB1522	rpoB^H481Y	0.25	rpoB^H481YgyrA^A26V	1
CB1524	CB1522	rpoB^H481Y	0.25	rpoB^H481YgyrA^G773V	2
CB1416	CB370	rpoB^H481Y	0.1	rpoB^H481YgyrA^L795S	0.5
CB1417	CB370	rpoB^H481Y	0.1	rpoB^H481YgyrA^G532V	0.5
CB1418	CB370	rpoB^H481Y	0.1	rpoB^H481YgyrA^D705N	0.5
CB1419	CB370	rpoB^H481Y	0.1	rpoB^H481YgyrA^G572D	1
CB1420	CB370	rpoB^H481Y	0.1	rpoB^H481YgyrA^G584V	0.5
CB1326	CB370	rpoB^H481Y	0.2	rpoB^H481YgyrA^S784F	0.5
CB1327	CB370	rpoB^H481Y	0.2	rpoB^H481Y gyrA^S84L	0.5
CB1421	CB809	rpoB^H481YparC^S80F	0.18	rpoB^H481YparC^S80FgyrA^S84L	1
CB1430	CB812	rpoB^H481YgyrA^S84L	0.18	rpoB^H481YparE^E474KgyrA^S84L	16
CB1333	CB815	rpoB^H481YparC^S80FgyrA^S84L	0.8	rpoB^H481YparC^S80FparE^L517FgyrA^S84L	16
CB1334	CB815	rpoB^H481YparC^S80FgyrA^S84L	0.8	rpoB^H481YparC^{S80F, Q27H}gyrA^S84L	8
CB1335	CB815	rpoB^H481YparC^S80FgyrA^S84L	0.8	rpoB^H481YparC^S80FparE^E474QgyrA^S84L	>16
CB1353	CB815	rpoB^H481YparC^S80FgyrA^S84L	0.53	rpoB^H481YparC^S80FparE^V458GgyrA^S84L	16
CB1354	CB815	rpoB^H481YparC^S80FgyrA^S84L	0.53	rpoB^H481YparC^S80FparE^R455HgyrA^S84L	16

NA, not applicable.