TABLE 4.
MICs for parent strains and their transformants carrying different recombinant plasmids
| Bacterium | MIC (μg/ml) of β-lactama:
|
||||||||
|---|---|---|---|---|---|---|---|---|---|
| MEM | IPM | AMX | TIC | CFZ | CXM | CTX | CAZ | ATM | |
| E coli | |||||||||
| DH5α | <0.25 | 0.25 | 8 | 8 | 4 | 4 | <0.12 | <0.12 | <0.12 |
| DH5α(pOXA-58-3)b | <0.25 | 2 | >256 | >1,024 | 8 | 4 | <0.12 | <0.12 | <0.12 |
| DH5α(pOXA-58-4)b | <0.25 | 0.25 | >256 | 256 | ND | ND | ND | ND | ND |
| A. baumannii | |||||||||
| TVICU53 | 16 | 64 | >256 | >1,024 | >128 | >128 | 64 | 128 | 64 |
| Ab290 | 0.25 | 0.25 | 32 | 16 | >128 | 32 | 8 | 4 | 16 |
| Ab290(pTVICU53)b | 16 | 32 | >256 | >1,024 | >128 | 32 | 8 | 4 | 16 |
| Ab290(pOXA-58-3)b | 16 | 64 | >256 | >1,024 | >128 | 32 | 8 | 4 | 16 |
| Ab290(pOXA-58-4)b | 0.5 | 1 | >256 | 256 | ND | ND | ND | ND | ND |
| ATCC 15151T | 0.5 | 0.5 | >256 | 8 | >128 | 128 | 16 | 8 | 64 |
| ATCC 15151T(pOXA-58-3)b | 32 | 32 | >256 | >1,024 | >128 | >128 | 16 | 8 | 128 |
a
AMX, amoxicillin; TIC, ticarcillin; CFZ, cefazolin, CXM, cefuroxime CAZ, ceftazidime; CTX, cefotaxime; ATM, aztreonam; IPM, imipenem; MEM, meropenem; ND, not done.
b
The plasmid in parentheses was transformed into the host cell indicated.