TABLE 3.
Plasma pharmacokinetic parameters of the metabolite, RO4957463, and AUC ratios of metabolite to parent following single-dose administration of 1,500 mg of tomopenem to subjects with various degrees of renal functiona
| Groupb | Cmax (μg/ml) | Tmax (h) | t1/2 (h) | AUC∞(μg·h/ml) | AUCM/P |
|---|---|---|---|---|---|
| A | 3.51 ± 0.81 | 1.01 (1.00-1.50) | 2.98 ± 0.36 | 18.5 ± 3.44 | 0.10 ± 0.01 |
| B | 4.31 ± 0.77 | 1.00 (0.98-1.50) | 5.02 ± 1.68 | 37.3 ± 12.9 | 0.12 ± 0.02 |
| C | 5.24 ± 1.70 | 5.00 (3.00-9.10) | 8.32 ± 3.45 | 115 ± 94.2 | 0.21 ± 0.09 |
| D | 9.63 ± 1.87 | 13.5 (12.0-24.0) | 25.3 ± 12.6 | 490 ± 139 | 0.49 ± 0.16 |
a
Data are means ± SD, except for Tmax values, which are median (range) values.
b
Each group included eight subjects.