TABLE 4.
Urine pharmacokinetic parameters of tomopenem and its major metabolite following single-dose administration of 1,500 mg of tomopenem to subjects with various degrees of renal functiona
| Parameter | Value for group
|
|||
|---|---|---|---|---|
| A | B | C | D | |
| Tomopenem parameters | ||||
| CLR (liters/h) | 4.63 ± 0.89 | 3.68 ± 0.94 | 1.98 ± 0.77 | 0.59 ± 0.19 |
| Ae (mg) | 862 ± 79.0 | 1,090 ± 220 | 939 ± 265 | 618 ± 270 |
| Ae (% dose) | 57.4 ± 5.3 | 72.6 ± 14.7 | 62.6 ± 17.7 | 41.2 ± 18.0 |
| RO4957463 parameters | ||||
| CLR (liters/h) | 13.2 ± 5.6 | 8.27 ± 2.9 | 3.91 ± 1.8 | 1.01 ± 0.5 |
| Ae (mg) | 240 ± 99.3 | 279 ± 107 | 281 ± 59.7 | 194 ± 120 |
| Ae (% dose) | 16.0 ± 6.62 | 18.6 ± 7.13 | 18.7 ± 3.98 | 13.1 ± 8.01 |
a
Data are means ± SD (n = 8 for each group).