TABLE 2.
Comparison of time-kill curve parameters for flucytosine, voriconazole, and micafungin combinations against C. glabrataa
| Treatment | ABTKC (log10 CFU·h/g) | AURKC (unitless) | Kmax (h−1) | Tmax (h) |
|---|---|---|---|---|
| 5FC | 434.1 ± 16.7* | −8.24 ± 0.55* | −0.57 ± 0.03* | 8 ± 0* |
| Vor | 143.1 ± 78.2** | −2.29 ± 1.93† | −0.16 ± 0.03** | 26 ± 4 |
| Mica | 268.5 ± 83.8 | −2.63 ± 2.65† | −0.34 ± 0.02 | 24 ± 0 |
| 5FC+Vor | 398.5 ± 47.9 | −7.19 ± 1.34 | −0.46 ± 0.10 | 8 ± 0 |
| Vor+Mica | 375.8 ± 8.2 | −6.59 ± 0.28 | −0.31 ± 0.01 | 24 ± 0 |
| 5FC+Mica | 429.1 ± 7.0 | −7.01 ± 0.55 | −0.48 ± 0.10 | 8 ± 0 |
| 5FC+Mica+Vor | 424.1 ± 5.2 | −8.18 ± 0.70 | −0.54 ± 0.06‡ | 8 ± 0‡ |
a
Data are means ± SD (n = 4). 5FC, flucytosine; Vor, voriconazole; and Mica, micafungin. Significant comparisons (P < 0.007) are marked as follows: *, 5FC > Vor or Mica alone; **, Vor < all treatments; †, all treatment combinations > Vor or Mica alone; ‡, 5FC+Mica+Vor > Vor, Mica, or Vor+Mica.