TABLE 3.
Comparison of time-kill curve parameters for flucytosine, voriconazole, and micafungin combinations against C. parapsilosisa
| Treatment | ABTKC (log10 CFU·h/g) | AURKC (unitless) | Kmax (h−1) | Tmax (h) |
|---|---|---|---|---|
| 5FC | 283.2 ± 22.4* | −5.95 ± 0.94* | −0.29 ± 0.11 | 24 ± 0 |
| Vor | 152.7 ± 15.4** | −2.72 ± 0.24‡ | −0.16 ± 0.01 | 24 ± 0 |
| Mica | 124.9 ± 17.6** | −2.59 ± 0.75‡ | −0.11 ± 0.03 | 30 ± 4 |
| 5FC+Vor | 350.5 ± 3.5† | −8.18 ± 0.16† | −0.55 ± 0.02† | 8 ± 0§ |
| Vor+Mica | 168.6 ± 4.4 | −4.75 ± 0.44 | −0.15 ± 0.01 | 18 ± 12 |
| 5FC+Mica | 263.1 ± 66.0 | −5.36 ± 0.48 | −0.20 ± 0.08 | 24 ± 0 |
| 5FC+Mica+Vor | 302.9 ± 9.9 | −6.58 ± 0.62 | −0.32 ± 0.03 | 12 ± 8 |
a
Data are means ± SD (n = 4). 5FC, flucytosine; Vor, voriconazole; and Mica, micafungin. Significant comparisons (P < 0.007) are marked as follows: *, 5FC > Vor, Mica, Vor+Mica; **, Vor or Mica alone < 5FC+Vor, 5FC+Mica, or 5FC+Mica+Vor; †, 5FC+Vor > all treatments alone or in combination; ‡, all treatment combinations > Vor or Mica alone; §, 5FC+Vor < all treatments except for 5FC+Mica+Vor.