TABLE 2.

Treatment of experimental endocarditis caused by MRSA 277 and GISA ATCC 700788

Treatment group	No. of sterile vegetations/total no. (%)	Median (IQRq) log10 CFU/g of vegetation
MRSA 277
Controla	0/20 (0)	9 (8.6-9.3)
Daptomycinb	13/18 (72)c,g	0 (0-1.5)d,i
Vancomycin RDe	7/20 (35)c,h	2 (0-5.6)d,j
Vancomycin HDf	9/18 (50)g,h	1 (0-2)i,j
GISA ATCC 700788
Controla	0/17 (0)	9.5 (8.3-9.8)
Daptomycinb	12/19 (63)k,m	2 (0-2)l,o
Vancomycin RDe	4/20 (20)k,n	6.6 (2-6.9)l,p
Vancomycin HDf	4/20 (20)m,n	2.4 (2-4)o,p

^aThe control animals were killed 18 h after the infection was started.

^bSimulating a regimen of 6 mg/kg q24h i.v.

^cP = 0.02.

^dP = 0.02.

^eVancomycin RD simulating treatment at 1 g q12h i.v.

^fVancomycin HD simulating treatment at 1 g q6h i.v.

^gP = 0.17.

^hP = 0.35.

ⁱP = 0.19.

^jP = 0.13.

^kP < 0.01.

^lP < 0.01.

^mP < 0.01.

ⁿP = 1.00.

^oP = 0.02.

^pP = 0.03.

^qIQR, interquartile range.