TABLE 2.
In vitro susceptibility to antifungal drugs of 75 Fusarium isolates by species
| Fusarium species (no. of isolates) | Test agent | G-MICb (μg/ml) | Cumulative no. of isolates with MICa (μg/ml) of:
|
||||||
|---|---|---|---|---|---|---|---|---|---|
| 0.25 | 0.50 | 1.00 | 2.00 | 4.00 | 8.00 | ≥16.0 | |||
| F. verticillioides (31) | Amphotericin B | 1.53 | 1 | 14 | 31 | ||||
| Itraconazole | 3.33 | 15 | 21 | 26 | 31 | ||||
| Posaconazole | 0.46 | 9 | 29 | 31 | |||||
| Voriconazole | 1.74 | 10 | 30 | 31 | |||||
| F. solani (19) | Amphotericin B | 1.25 | 1 | 2 | 13 | 19 | |||
| Itraconazole | >16 | 19 | |||||||
| Posaconazole | 15.21 | 1 | 19 | ||||||
| Voriconazole | 9.21 | 1 | 2 | 5 | 13 | 19 | |||
| F. proliferatum (10) | Amphotericin B | 1.7 | 5 | 9 | 10 | ||||
| Itraconazole | >16 | 10 | |||||||
| Posaconazole | 6.4 | 2 | 5 | 7 | 10 | ||||
| Voriconazole | 4.2 | 2 | 4 | 7 | 10 | ||||
| F. oxysporum (9) | Amphotericin B | 2.3 | 1 | 7 | 9 | ||||
| Itraconazole | >16 | 9 | |||||||
| Posaconazole | 2.7 | 6 | 9 | ||||||
| Voriconazole | 4.0 | 2 | 8 | 9 | |||||
| F. subglutinans (3) | Amphotericin B | 3.3 | 1 | 3 | |||||
| Itraconazole | 10.8 | 1 | 3 | ||||||
| Posaconazole | 10.75 | 1 | 3 | ||||||
| Voriconazole | 5.6 | 1 | 3 | ||||||
| F. dimerum (1) | Amphotericin B | 1 | |||||||
| Itraconazole | 1 | ||||||||
| Posaconazole | 1 | ||||||||
| Voriconazole | 1 | ||||||||
| Fusarium spp. (2) | Amphotericin B | 2 | |||||||
| Itraconazole | 1 | 2 | |||||||
| Posaconazole | 1 | 2 | |||||||
| Voriconazole | 2 | ||||||||
a
The MIC was defined as the lowest concentration that produced a 100% reduction in growth compared with the growth of the control under drug-free conditions after 48 h of incubation at 35°C.
b
G-MIC, geometric mean MIC.