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. 2008 Apr 14;52(7):2389–2394. doi: 10.1128/AAC.01422-07

TABLE 2.

Pharmacokinetic results for BPR after a single s.c. dose in immunocompromised, infected BALB/c micea

Dosing regimen (mg/kg) Cmax (mg/liter) Tmax (h) AUC0-∝ (mg·h/liter) VF (liter/kg) Half-life (h) CL (ml/h/kg)
1 1.74 0.48 1.84 0.19 0.25 0.54
2.5 2.91 0.41 2.57 0.63 0.45 0.97
10 19.75 0.15 15.79 0.38 0.42 0.63
25 38.59 0.47 35.25 0.41 0.40 0.71
a

Tmax, time required to achieve Cmax; AUC0-∝, AUC from time zero to infinity; VF, volume of distribution; CL, clearance.