Fig. 4.

A: Glucose tolerance and insulin sensitivity after treatment with vehicle or vehicle containing L-4F. After 6 weeks of treatment with vehicle or vehicle containing L-4F, obese mice were injected intraperitoneally with 2 g/kg of glucose, and plasma glucose levels were determined as described in Materials and Methods for the intraperitoneal glucose tolerance test. *P < 0.05 versus vehicle-treated obese mice. B: After 6 weeks of treatment with vehicle or vehicle containing L-4F, obese mice were injected intraperitoneally with 2.0 U/kg of insulin, and plasma glucose levels were determined as described in Materials and Methods for the intraperitoneal insulin tolerance test. *P < 0.001 versus L-4F-treated obese mice, 0 min. The results are expressed as mean ± SEM; n = 4.