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. 1999 Dec 7;96(25):14354–14359. doi: 10.1073/pnas.96.25.14354

Figure 1.

Figure 1

The chicken β-globin gene cluster. The diagram on top shows the positions of the globin genes and the β/ɛ enhancer; the erythroid-specific hypersensitive sites (HS1, 2, and 3) and the constitutive 5′HS4 site are shown with arrows. The original 1.2-kb chicken β-globin insulator and the core insulator with fine mapping of the hypersensitive site are schematically shown underneath. The black boxes represent DNA-binding sites for nuclear factors; (II/III-Ins)Q is a DNA fragment composed of four copies of a minimal element (15), a 90-bp DNA fragment that includes the DNA-binding sequences FII and FIII defined previously (15). The four copies of the 90-bp fragment are organized head-to-tail to form a 430-bp fragment.