Fig. 6.

Infection and LPS decrease LDL receptor protein in the liver. A: Nine WT mice (columns 1–9) were euthanized at 3 days after inoculation with K. pneumoniae or PBS as described for Figure 1. B: Fasted WT mice were euthanized at 18 h after intraperitoneal injection of PBS (Control) or LPS (20 or 100 μg/25 g body weight) using three mice per treatment group. Plasma apoE and the indicated liver proteins were measured by Western blotting of equal volumes of plasma or equal amounts of liver total membrane protein; semiquantitative analysis of the bands was performed as described in Materials and Methods. The experiments were repeated with similar results. SR-BI, scavenger receptor class B type I.