Fig. 6.

Hematoxylin-eosin (H and E) staining of liver, spleen, and small intestine of wild-type, and PBS- or G-hLAL-treated lal^−/− mice. Sections were from age-matched lal^+/+ (A, D, G), lal^−/− untreated mice (B, E, H), or G-hLAL-treated with 72 U (C, F, I). The lipid-laden Kupffer cells (B), spleen (E), and small intestine (H) macrophages were clearly evident in untreated lal^−/− mice (arrows). Complete correction of lipid storage in macrophages (arrows in C, I) was observed in macrophages of these tissues of G-hLAL-treated mice. Hepatocytes was not corrected (arrowhead). Top row, liver (Kupffer cells); middle row, spleen; bottom row, small intestine.