Figure 3. Map of S. pneumoniae genomes [8]–[44], [45] and the unfinished S. mitis genome (JCVI CMR) in the area that includes the IgA1 protease gene (iga).

The map shows synteny apart from the absent iga gene in S. mitis NCTC 12261, in agreement with its lack of IgA1 protease activity, and apart from an additional iga paralog (zmpD) in some pneumococcus strains (INV200 and 23F) and in two strains of S. mitis [46].