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. Author manuscript; available in PMC: 2008 Jul 8.
Published in final edited form as: Nat Neurosci. 2007 Sep;10(9):1116–1124. doi: 10.1038/nn1944

Figure 1.

Figure 1

Subgenual cingulate cortex activation across studies. (a) Transient sadness in healthy volunteers increases activity (red) in Cg25 (arrow) measured with positron emission tomography (PET) (from ref. 12. Reprinted with permission from the American Journal of Psychiatry, copyright 1999, American Psychiatric Association.). (b) Decreased Cg25 activity (green) with chronic fluoxetine treatment for depression. (c) Cg25 decrease (green) in recovery with chronic fluoxetine from Parkinson’s disease–related depression. (d) Natural recovery with decreased Cg25 activity (green) in patients treated with placebo. Panels b–d reprinted from ref. 11 by permission of Oxford University Press. (e) Predictors of response in subjects responding to CBT for depression included low pretreatment Cg25 activity (red) (from ref. 15. Reprinted with permission from the American Journal of Psychiatry, copyright 1999, American Psychiatric Association.). (f) Subgenual cortical decreased activity (red) was common in responders compared with nonresponders for those responding both to citalopram and to CBT for social phobia (from ref. 16. Reprinted from Archives of General Psychiatry, copyright 2002, American Medical Association. All rights reserved.).