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. 1999 Dec 7;96(25):14372–14377. doi: 10.1073/pnas.96.25.14372

Figure 2.

Figure 2

Rescue of Hoxc8 deregulation in Mll/Bmi-1 double-mutant embryos. (A–D) Hoxc8 whole-mount in situ hybridization of E9.5 embryos. (E–H) In situ hybridization sections of E12.5 embryos. Arrows indicate the wild-type boundary of expression: specifically, the anterior edge of somite 14 (A–D) and the 12th prevertebral body (E–H). A posterior shift and decreased expression of Hoxc8 were observed in Mll+/− embryos (B and F). An anterior shift of Hoxc8 boundaries in somites and presomitic mesoderm (arrowhead in C) was seen in Bmi-1−/− embryos (C and G). The Mll+/−Bmi-1−/− double mutants (D and H) restored the anterior boundaries to wild-type positions (A and E) but displayed decreased levels of expression.