Figure 4.
Expression of Hox c8-lacZ is reserved by MLL. (a) MEFs from Mll+/+ and Mll−/− embryos were transfected with a Hoxc8-lacZ construct, demonstrating integration site independent regulation of Hoxc8 in stable transfectant clones. (b) Expression of human MLL (hMLL) results in the expression of the integrated Hoxc8-lacZ reporter but not the endogenous Hoxc8 locus.