Table 3.
Increased zygotic snf+ dose kills SxlM12/Y and SxlMf1/Y males
| Progeny class (cross†) | Males
|
Siblings for viability reference*
|
||||
|---|---|---|---|---|---|---|
| Sxl allele(s) | P(snf+) dose | Other key mutations | Relative viability | Zygotic genotype | n | |
| 1 (A) | SxlM12 | 0 | 93% | SxlM12/+ ♀ | 1,044 | |
| 2 (A) | SxlM12 | 1 | <0.1% | SxlM12/+; P(snf+)/+ ♀ | 1,086 | |
| 3 (B) | SxlM12 and Sxl+ | 0 | 33% | X∧X/Y ♀ | 1,101 | |
| 4 (C) | SxlM12 | 2 | vir2f/vir2f | 93% | SxlM12/+; P(snf+) vir2f/+ ♀ | 208 |
| 5 (D) | SxlM12 | 0 | P(vir+)/+ | 118% | +/Y; P(vir+)/+ ♂ | 61 |
| 6 (E) | SxlMf1 | 0 | 97% | X∧X/Y ♀ | 196 | |
| 7 (E) | SxlMf1 | 1 | 57% | X∧X/Y; P(snf+)/+ ♀ | 396 | |
| 8 (E) | SxlMf1 | 2 | 3% | X∧X/Y; P(snf+)P(snf+)/+ ♀ | 234 | |
For crosses A, C, and D, the 100% value for male viability equals this sibling class. For crosses B and E, expected sex-chromosome segregation ratios are not 1:1; hence, a multiplier for estimating the 100% value from the sibling class was determined from control crosses of experimental females to w/Y males [cross B: 0.87 (617♂/709♀); cross E: 1.44 (141♂/98♀)].
† A, w SxlM12 ct6 ☿☿ × ♂♂ w/Y; P{snf+w+mC}108/+. B, y w f: =/y+ct+Y, Sxl+ ☿☿ × ♂♂ w SxlM12ct6/Y. C, w SxlM12ct6/Binsinscy; P{snf+w+mC}108 vir2fbw/CyO ☿☿ × ♂♂ w SxlM12ct6/Y; P{snf+w+mC}108 vir2fbw. D, y w f: =/Y ☿☿ × ♂♂ w SxlM12ct6/Y; P{vir+w+mC}6.2/+. E, y w f: =/Y; P{snf+w+mC}108 and P{snf+w+mC}19/+ ☿☿ × ♂♂ w SxlMf1ct6/Y.