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. 1999 Dec 7;96(25):14459–14463. doi: 10.1073/pnas.96.25.14459

Figure 1.

Figure 1

M. tuberculosis-induced TNF-α production depends on TLR2. RAW-TT10 cells transiently transfected with a control plasmid (Top), MyD88-dominant negative (MyD88-DN, Middle), or TLR2-P681H (Bottom) were analyzed for induction of TNF-α after stimulation with virulent M. tuberculosis (H37Rv), avirulent M. tuberculosis (H37Ra), or LPS. The thin, solid lines indicate TNF-α produced in cells not expressing the transgene, and the bold lines indicate TNF-α produced in cells expressing the indicated transgene. The dotted lines indicate background, unstimulated TNF-α production. In each case, the y axis represents relative cell number.