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. Author manuscript; available in PMC: 2008 Jul 9.

Published in final edited form as: J Immunol. 2005 Jan 1;174(1):143–154. doi: 10.4049/jimmunol.174.1.143

Tolerance induction induces high Th2 cytokine production in CD200^−/−, but not WT, mice immunized with peptide 1-20. CD200^−/− and WT mice were tolerized with peptide 1-20 or control PBS 10 days before immunization with peptide 1-20. Groups of at least three mice were killed on day 16, 21, or 28, and cytokine responses of splenocytes restimulated with peptide 1-20 were measured after 48 h. Cytokine data are given as picograms per milliliter and are expressed as the mean ± SEM of cumulative data from three separate experiments. *, p < 0.05; **, p < 0.03 (compared with sham-tolerized mice on same genetic background, by Mann-Whitney test). ‡, p < 0.05; ‡‡, p < 0.01 (compared with WT tolerized mice). , WT sham-tolerized; , WT peptide-tolerized; , CD200^−/− sham-tolerized; , CD200^−/− peptide-tolerized.

Inline graphic — Tolerance induction induces high Th2 cytokine production in CD200^−/−, but not WT, mice immunized with peptide 1-20. CD200^−/− and WT mice were tolerized with peptide 1-20 or control PBS 10 days before immunization with peptide 1-20. Groups of at least three mice were killed on day 16, 21, or 28, and cytokine responses of splenocytes restimulated with peptide 1-20 were measured after 48 h. Cytokine data are given as picograms per milliliter and are expressed as the mean ± SEM of cumulative data from three separate experiments. *, p < 0.05; **, p < 0.03 (compared with sham-tolerized mice on same genetic background, by Mann-Whitney test). ‡, p < 0.05; ‡‡, p < 0.01 (compared with WT tolerized mice). , WT sham-tolerized; , WT peptide-tolerized; , CD200^−/− sham-tolerized; , CD200^−/− peptide-tolerized.