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. 2008 Aug;98(8):1372–1381. doi: 10.2105/AJPH.2007.124610

TABLE 3—

Rate Ratios (RRs) and 95% Confidence Intervals (CIs) for the Association Between Specific Hand-Hygiene Interventions and Each Illness Outcome

Gastrointestinal Illness (N = 24) Respiratory Illness (N = 16) Combined Illnesses (N = 10)
Intervention No. of Studies RRa (95% CI) No. of Studies RRa (95% CI) No. of Studies RRa (95% CI)
Education vs control 7 0.69 (0.50, 0.95) 4 0.86 (0.73, 1.00) NA NA
Nonantibacterial soap with education vs controlb,c 6 0.61 (0.43, 0.88) 1 0.49 (0.40, 0.61) 2 0.94 (0.74, 1.18)
Antibacterial soap with education vs controlb,c 2 0.59 (0.33, 1.06) 1 0.50 (0.40, 0.61) NA NA
Antibacterial soap vs nonantibacterial soapc 2 0.99 (0.54, 1.83) 2 1.00 (0.84, 1.19) 1 0.96 (0.71, 1.30)
Alcohol-based hand sanitizer vs control NA NA NA NA 2 0.74 (0.59, 0.93)
Alcohol-based hand sanitizer with education vs controlb 5 0.77 (0.52, 1.13) 6 0.93 (0.84, 1.03) 3 0.79 (0.67, 0.93)
Benzalkonium chloride–based hand sanitizer vs control 2 0.58 (0.30, 1.12) 2 0.60 (0.45, 0.81) 2 0.59 (0.45, 0.78)

aPooled or single-study RRs.

bIndicates a layered intervention.

cStudies that tested more than a single intervention.44,45