Figure 2.

Enzyme activities in mutant and control mice. (A) Activity, mean ± SD, of α-N-acetylglucosaminidase in tail clippings of 10-d-old mice. The mice of the second backcross generation numbered 65 for +/+, 102 for +/−, and 65 for −/−. There was no change in enzyme level in subsequent backcross generations. (B) α-N-acetylglucosaminidase activity in various tissues of 1-mo-old +/+ and +/− mice (two mice each for brain and three for other tissues); the activity in −/− mice is not shown, because it was zero in every case. (C) Ratio of activity of other enzymes in liver and brain of +/+ and −/− mice; one 5-mo-old mutant mouse was used for liver and two for brain, with one control mouse of the same age. Abbreviations for enzymes: β-Gal, β-galactosidase; α-Glu, α-glucosidase; β-GlcA, β-glucuronidase; β-Hex, β-hexosaminidase; α-l-Idu, α-l-iduronidase; α-Neu, α-N-acetylneuraminidase.