TABLE 6.

Genes downregulated by the G648D mutation in Upc2p

CandidaDB namea	Common nameb	orf19 no.c	GO annotation (molecular function)d	Fold decrease in expression
				S2 vs S1		UPC2S2-1 vs UPC2S1-1
						Strain A		Strain B
				Expt 1	Expt 2	Expt 1	Expt 2	Expt 1	Expt 2
COQ1		orf19.7478	trans-Hexaprenyltranstransferase activity	−2.8	−2.9	−1.5	−2.5	−2.4	−3.8
MAS2		orf19.6295	Mitochondrial processing peptidase activity	−1.6	−1.7	−1.6	−2.3	−2.7	−2.9
MET14	MET14	orf19.946	Adenylylsulfate kinase activity	−5.6	−6.9	−2.3	−2.9	−3.5	−3.7
MET3	MET3	orf19.5025	Sulfate adenylyltransferase (ATP) activity	−4.2	−3.8	−3.3	−4.0	−3.5	−5.9
PET127		orf19.2309	RNA binding	−1.7	−1.8	−2.0	−4.4	−7.7	−5.9
IPF11801		orf19.2798	Helicase activity	−1.6	−1.7	−2.3	−2.2	−2.0	−1.8
IPF14872		orf19.4133		−2.0	−1.8	−1.8	−3.5	−2.3	−4.0
IPF20118		orf19.3846		−3.8	−4.4	−3.6	−3.1	−1.7	−1.6
IPF525		orf19.7085		−2.4	−2.2	−1.7	−3.1	−1.7	−1.7
IPF6504		orf19.1544		−2.1	−2.0	−1.8	−1.5	−1.7	−1.6
IPF7334		orf19.3724		−2.3	−2.2	−1.6	−3.1	−1.8	−3.4

^aGene name from CandidaDB (http://genolist.pasteur.fr/CandidaDB/).

^bGene name from CGD (http://www.candidagenome.org/).

^corf19 nomenclature according to assembly 19.

^dGene Ontology (GO) (4) annotation found at CGD (http://www.candidagenome.org/).