FIG. 2.

The effect of actin and microtubule polymerization on F. tularensis LVS invasion of lung epithelial cells. TC-1 cells were treated with designated concentrations of cytochalasin D (A) or colchicine (B). Results are expressed as the percentage of LVS, Salmonella, or Campylobacter organisms that survived gentamicin treatment relative to that for the sample without inhibitor inoculated with the same organism (defined as 100% invasion). *, Data are significantly different from untreated control data (P < 0.01 by paired two-tailed t test).