FIG. 3.

The effect of PI 3-kinase and tyrosine kinase activity on LVS invasion of lung epithelial cells. Wortmannin (A) and genistein (B) were added to TC-1 cells at the indicated concentrations. Results are expressed as the percentage of LVS or control organisms that survived gentamicin treatment relative to that for the sample without inhibitor inoculated with the same organism (defined as 100% invasion). *, Data are significantly different from untreated control data (P < 0.01 by paired two-tailed t test).