SHIP is required to control Salmonella but not Citrobacter replication in vivo. (A) ship+/+and ship−/− mice were infected orally with 106 serovar Typhimurium SL13344 and sacrificed at 2 days postinfection. Colons, small intestines (SI), livers, MLN, and spleens were harvested from the mice, homogenized, and plated to enumerate the bacterial load. (B) ship+/+and ship−/− mice were infected i.p. with 102 serovar Typhimurium SL13344 and sacrificed at 5 days postinfection. Colons, small intestines, livers, MLN, and spleens were harvested from the mice, homogenized, and plated to enumerate bacterial load. (C) ship+/+and ship−/− mice were infected orally with 108 C. rodentium DBS100 and sacrificed at 7 days postinfection. Colons were harvested from the mice, homogenized, and plated to enumerate the bacterial load. For all figures, three independent experiments were performed with a total of 12 animals for both ship+/+and ship−/− mice.