TABLE 2.
Hypercytokinemia is observed at the systemic level in mice infected with F. tularensis subsp. novicida
| Mediator | Concna
|
||||
|---|---|---|---|---|---|
| Control | 6 hpi | 1 dpi | 3 dpi | 4 dpi | |
| Gamma interferon | <68 | <68 | <68 | 4,130 ± 1,656 | 1,184 ± 476 |
| IL-6 | <14 | <14 | <14 | 10,197 ± 6,145 | 13,662 ± 5,821 |
| IL-18b | 0.83 | 1.3 | 1.2 | 22.8 ± 4.2 | 41.3 ± 11.3 |
| CXCL2 | <7.2 | <7.2 | 14.1 | 2,182 ± 999 | 7,666 ± 2,566 |
| CCL7 | 156 | 147 | 142 | 9,737 ± 1,062 | 8,946 ± 1,689 |
| CXCL10 | <40 | 45 | <40 | 20,765 ± 2,632 | 20,465 ± 2,932 |
| CCL2 | 43 | 49 | 64 | 10,559 ± 1,628 | 6,053 ± 3,158 |
| CXCL1b | <0.17 | <0.17 | <0.17 | 13.5 ± 3.5 | 34.3 ± 13.5 |
| XCL1 | <85 | <85 | <85 | 723 ± 83.5 | 897 ± 159 |
| CCL12 | <46 | <46 | <46 | 2,840 ± 892 | 4,857 ± 748 |
| CCL4 | <78 | <78 | <78 | 4,127 ± 1,417 | 6,450 ± 2,255 |
| CCL10b | 5.9 | 10.5 | 9.8 | 128 ± 45.9 | 186 ± 66.5 |
| CCL19b | 0.07 | 0.07 | 0.08 | 0.43 ± 0.09 | 0.63 ± 0.22 |
| OSMb | <0.13 | <0.13 | <0.13 | 0.90 ± 0.04 | 1.04 ± 0.24 |
| CCL5 | <48 | <48 | <48 | 103 ± 19.6 | 206 ± 54.8 |
| IL-4 | <74 | <74 | <74 | 173 ± 29.8 | 209 ± 43.9 |
| IL-10 | 109 | 137 | 140 | 5,380 ± 968 | 8,973 ± 2,199 |
| IL-11 | <87 | <87 | <87 | 341 ± 64 | 459 ± 9.3 |
a
The systemic concentrations of cytokines and chemokines in the serum of mock-infected animals and animals infected with F. tularensis subsp. novicida at 6 hpi and 1, 3, and 4 dpi were determined using Luminex assays and are expressed in pg/ml unless indicated otherwise. The values are averages for measurements obtained for the control and early infection time points for biological duplicates. The values for 3 and 4 dpi were derived from the averages of biological triplicates.
b
The values are expressed in ng/ml. The data for 3 and 4 dpi are significantly different (P < 0.05 to P < 0.005) than the control data for 6 hpi and 1 dpi.