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40-kDa OMP-specific Ab responses after nasal vaccination with 40-kDa OMP plus CT. Apoeshl mice were nasally immunized with 10 μg of 40-kDa OMP plus 1 μg of CT on days 0, 7, and 14 (▪) or not immunized (□). Serum and saliva samples were collected on day 21 and assessed for 40-kDa OMP-specific serum IgG (A) and saliva IgA (B) Abs. The results are expressed as the mean ± the SD for six mice per group. *, P < 0.01; **, P < 0.05 (compared to the control group).
