Figure 2.

Effects of p53 expression. (A) Mutant or wt p53- and p73-inducible clones were assayed for nuclear morphology by fluorescence microscopy at the indicated time points. Red bars represent p53- or p73-induced cells, and blue bars represent uninduced cells. At least 200 cells were counted for each determination. (B) Morphology after p53 induction. The same fields are shown as viewed under phase contrast or fluorescence microscopy. The four panels at Left were p53 wtA cells, and the four panels at Right were p53 mut cells grown in induction (Induced) or normal medium (Uninduced) for 24 hr.