TABLE 1.

In vitro susceptibilities of Candida spp. isolates to anidulafungin, caspofungin, and micafungin as determined by the Sensititre YeastOne antifungal plate and CLSI BMD methods^a

Organism	Antifungal agent	Study site (no. of isolates)	Test method	MIC (μg/ml)b			EA (%)
				Range	50%	90%
C. albicans	Anidulafungin	1 (58)	YstOne	≤0.008-0.12	0.06	0.12	100
			Ref.	≤0.008-0.06	0.03	0.06
		2 (58)	YstOne	≤0.008-0.25	0.016	0.06	100
			Ref.	≤0.008-0.25	0.016	0.03
		3 (58)	YstOne	≤0.008-0.12	0.06	0.12	100
			Ref.	≤0.008-0.06	0.03	0.06
	Caspofungin	1 (58)	YstOne	0.016-0.12	0.03	0.06	100
			Ref.	≤0.008-0.25	0.06	0.06
		2 (58)	YstOne	0.016-0.25	0.03	0.06	100
			Ref.	0.016-0.5	0.03	0.06
		3 (58)	YstOne	0.03-0.25	0.06	0.12	100
			Ref.	0.03-0.5	0.06	0.06
	Micafungin	1 (58)	YstOne	≤0.008-0.03	≤0.008	0.016	100
			Ref.	≤0.008-0.06	0.016	0.03
		2 (58)	YstOne	≤0.008-0.06	0.016	0.03	100
			Ref.	0.016-0.12	0.016	0.03
		3 (58)	YstOne	≤0.008-0.016	≤0.008	0.016	100
			Ref.	≤0.008-0.06	0.016	0.03
C. glabrata	Anidulafungin	1 (29)	YstOne	0.03-2	0.06	0.12	100
			Ref.	0.03-4	0.06	0.25
		2 (29)	YstOne	0.03-0.25	0.12	0.12	100
			Ref.	0.03-0.25	0.12	0.12
		3 (29)	YstOne	0.03-.025	0.12	0.12	100
			Ref.	0.03-0.12	0.06	0.06
	Caspofungin	1 (29)	YstOne	0.03->8	0.06	0.12	100
			Ref.	0.03->8	0.06	0.12
		2 (29)	YstOne	0.06-1	0.12	0.25	100
			Ref.	0.06-1	0.12	0.25
		3 (29)	YstOne	0.06-0.5	0.12	0.25	100
			Ref.	0.03-0.5	0.06	0.12
	Micafungin	1 (29)	YstOne	≤0.008-8	≤0.008	0.016	100
			Ref.	≤0.008-8	0.016	0.016
		2 (29)	YstOne	≤0.008-0.12	0.016	0.03	100
			Ref.	≤0.008-0.25	0.016	0.03
		3 (29)	YstOne	≤0.008-0.016	≤0.008	0.016	100
			Ref.	≤0.008-0.03	0.016	0.016
C. tropicalis	Anidulafungin	1 (26)	YstOne	0.016-0.5	0.12	0.25	100
			Ref.	0.016-0.06	0.03	0.06
		2 (21)	YstOne	≤0.008-0.5	0.016	0.06	100
			Ref.	≤0.008-0.5	0.016	0.12
		3 (26)	YstOne	0.06-0.25	0.12	0.12	100
			Ref.	0.016-0.12	0.03	0.06
	Caspofungin	1 (26)	YstOne	0.016-0.12	0.03	0.12	100
			Ref.	0.016-0.06	0.03	0.06
		2 (21)	YstOne	0.016-4	0.03	0.06	100
			Ref.	0.03-4	0.03	0.12
		3 (26)	YstOne	0.03-0.25	0.06	0.25	100
			Ref.	0.03-0.25	0.06	0.06
	Micafungin	1 (26)	YstOne	0.016-0.03	0.016	0.03	100
			Ref.	≤0.008-0.06	0.03	0.06
		2 (21)	YstOne	≤0.008-2	0.016	0.03	100
			Ref.	≤0.008-2	0.016	0.06
		3 (26)	YstOne	≤0.008-0.06	0.016	0.016	100
			Ref.	0.016-0.06	0.03	0.06
C. parapsilosis	Anidulafungin	1 (30)	YstOne	0.5-2	1	2	100
			Ref.	1-4	2	2
		2 (30)	YstOne	0.03-1	0.25	1	100
			Ref.	0.016-2	0.12	0.5
		3 (30)	YstOne	0.5-4	1	2	100
			Ref.	0.5-4	1	2
	Caspofungin	1 (30)	YstOne	0.25-2	0.5	1	100
			Ref.	0.25-1	0.5	1
		2 (30)	YstOne	0.016-0.5	0.12	0.25	100
			Ref.	0.03-1	0.25	0.5
		3 (30)	YstOne	0.25-2	0.5	1	100
			Ref.	0.12-1	0.5	0.5
	Micafungin	1 (30)	YstOne	0.25-2	0.5	1	100
			Ref.	0.5-2	1	2
		2 (30)	YstOne	0.03-0.5	0.25	0.25	100
			Ref.	0.016-1	0.25	0.5
		3 (30)	YstOne	0.25-2	0.5	1	100
			Ref.	0.25-2	1	2
C. krusei	Anidulafungin	1 (27)	YstOne	0.06-0.25	0.12	0.12	100
			Ref.	0.03-0.5	0.25	0.25
		2 (27)	YstOne	0.03-0.12	0.12	0.12	100
			Ref.	0.016-0.12	0.06	0.12
		3 (27)	YstOne	0.06-0.5	0.12	0.25	100
			Ref.	0.03-0.25	0.06	0.12
	Caspofungin	1 (27)	YstOne	0.12-0.5	0.25	0.5	100
			Ref.	0.12-1	0.5	0.5
		2 (27)	YstOne	0.06-0.5	0.25	0.5	100
			Ref.	0.06-0.25	0.25	0.25
		3 (27)	YstOne	0.12-0.5	0.25	0.5	100
			Ref.	0.06-1	0.12	0.5
	Micafungin	1 (27)	YstOne	0.016-0.12	0.12	0.12	100
			Ref.	0.03-0.12	0.06	0.12
		2 (27)	YstOne	0.016-0.25	0.12	0.12	100
			Ref.	0.016-0.25	0.12	0.25
		3 (27)	YstOne	0.06-0.25	0.12	0.12	100
			Ref.	0.03-0.25	0.12	0.12
C. lusitaniae	Anidulafungin	1 (25)	YstOne	0.06-0.25	0.12	0.25	100
			Ref.	0.06-1	0.5	0.5
		2 (25)	YstOne	≤0.008-0.12	0.12	0.12	100
			Ref.	≤0.008-0.25	0.12	0.12
		3 (25)	YstOne	0.12-2	0.25	0.5	100
			Ref.	0.06-2	0.25	1
	Caspofungin	1 (25)	YstOne	0.016-1	0.12	0.25	100
			Ref.	0.06-1	0.25	0.5
		2 (25)	YstOne	≤0.008-0.25	0.06	0.12	100
			Ref.	≤0.008-0.25	0.06	0.25
		3 (25)	YstOne	0.03-0.25	0.25	0.25	100
			Ref.	0.06-0.5	0.5	0.5
	Micafungin	1 (25)	YstOne	0.016-0.25	0.06	0.25	100
			Ref.	0.06-0.5	0.12	0.5
		2 (25)	YstOne	≤0.008-0.06	0.03	0.06	100
			Ref.	≤0.008-0.12	0.06	0.12
		3 (25)	YstOne	0.016-1	0.06	0.5	100
			Ref.	0.03-2	0.12	0.25
Candida spp.	Anidulafungin	1 (6)	YstOne	≤0.008-2	1		100
			Ref.	0.03-2	1
		2 (10)	YstOne	0.016-1	0.25	0.5	100
			Ref.	0.03-0.5	0.25	0.5
		3 (8)	YstOne	0.06-0.12	0.06		100
			Ref.	0.016-0.12	0.06
	Caspofungin	1 (6)	YstOne	≤0.008-0.5	0.25		100
			Ref.	0.03-0.5	0.5
		2 (10)	YstOne	0.016-0.25	0.12	0.25	100
			Ref.	0.016-0.25	0.12	0.25
		3 (8)	YstOne	0.016-0.03	0.03		100
			Ref.	0.016-0.12	0.06
	Micafungin	1 (6)	YstOne	0.016-1	0.25		100
			Ref.	0.03-2	0.5
		2 (10)	YstOne	0.016-0.5	0.12	0.5	100
			Ref.	0.03-0.5	0.12	0.25
		3 (8)	YstOne	≤0.008-0.06	0.016		100
			Ref.	0.016-0.12	0.03

^aAbbreviations: YstOne, YeastOne; Ref., reference method.

^b50%, MIC encompassing 50% of all isolates tested; 90%, MIC encompassing 90% of all isolates tested.