TABLE 1.
Summary of the biochemical and biomechanical properties of pseudotyped virus Env gp120-CD4 bond and purified gp120-CD4 bond using the Bell modela
| Molecular pair | Dissociation rate, koff0 (s−1) | Adhesion strength, F (pN), at loading rate of:
|
Relative compliance xβ (nm) | Source or reference | |
|---|---|---|---|---|---|
| 200 pN/s | 500 pN/s | ||||
| gp120-CD4 (pseudotyped) | 3.73 ± 0.45 | 22 ± 1 | 29 ± 1 | 0.34 ± 0.06 | This work |
| gp120-CD4 (purified) | 4.10 ± 0.20 | 26 ± 1 | 34 ± 1 | 0.14 ± 0.01 | 8 |
| P-selectin/PSGL-1 | 0.22 ± 0.05 | 82 | 130 | 0.14 ± 0.01 | 18 |
a
Values are means ± standard errors. The values for P-selectin/PSGL-1 are used for comparison.