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. 2008 May 14;82(14):7089–7099. doi: 10.1128/JVI.00570-08

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FIG. 4. — Entry and coreceptor usage efficiencies of R5, R5X4, and X4 SHIV viruses. (A) Relative entry into U87.CD4 (closed bars), U87.CD4.CXCR4 (open bars), and U87.CD4.CCR5 (hatched bars) cells of luciferase reporter virus expressing Env of R5 SHIV_SF162P3N (P3N), X4 SHIV_BR24N (BR24N), R5X4 (HI₂₀), and V3 loop recombinant EnvP3N(HI-V3). (B) Blocking of P3N (•) and R5X4 (□) virus entry into U87.CD4.CCR5 cells with increasing concentrations of the CCR5 inhibitor PSC-RANTES. (C) Blocking of BR24N (▵) and R5X4 (□) virus entry into U87.CD4.CXCR4 cells with increasing concentrations of the CXCR4 inhibitor AMD3100. Data shown are means ± standard errors of the mean of at least three independent experiments. RLU, relative light units.