FIG. 7.

Model of gC and gE on the virion envelope, blocking antibody access and enabling the interaction of glycoproteins that are required for fusion and entry. At the left, gC and gE on the WT virus block access of the antibodies, which enables the interaction between gB and gD that is required for fusion and entry. On the right, gC and gE on the gC/gE mutant virus fail to block antibody access. Our results suggest that antibodies must bind to at least two of the glycoproteins gB, gD, or gH/gL, to prevent glycoprotein interactions and inhibit entry.