FIG. 5.

Characteristics of vaccinia virus ORFs, expressed as RTS reaction products, grouped by population prevalence of T-cell recognition. ORFs were considered positive in subjects sampled twice if either time point was positive. Top: presence or absence of vaccinia virus ORFs in virions, determined as described in the text, versus the prevalence group for CD4 responses. Middle: relationship between prevalence of CD4 responses and weight percent of vaccinia virion proteins as reported by Chung et al. (14). The six ORFs with the highest population prevalence of CD4 responses are indicated with arrows. Bottom: length in amino acids (mean ± 1.95 times the standard deviation) of vaccinia virus ORFs versus the prevalence group for CD4 responses.